Chicken Bubble Biscuit Bake Casserole Recipe
Introduction
Chicken Bubble Biscuit Bake is a comforting and easy casserole that combines tender chicken, creamy vegetables, and flaky biscuits for a satisfying meal. Perfect for busy weeknights, it brings together simple ingredients into a warm, cheesy dish everyone will love.

Ingredients
- 2 cups cooked chicken (shredded or diced, rotisserie works great)
- 1 (10.5 oz) can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
- 1 (16 oz) can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Step 1: Preheat oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish.
- Step 2: In a large bowl, combine cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth.
- Step 3: Fold the quartered biscuit dough pieces into the chicken mixture until coated.
- Step 4: Pour the mixture into the prepared baking dish and spread evenly. Sprinkle shredded cheese over the top.
- Step 5: Cover the dish with foil and bake for 20 minutes. Remove the foil and bake for an additional 10 to 15 minutes, until biscuits are puffed, golden, and fully cooked.
- Step 6: Optional: Brush the top with melted butter for extra richness. Let the casserole cool slightly before serving.
Tips & Variations
- Use leftover rotisserie chicken for added flavor and convenience.
- Swap cream of chicken soup with cream of mushroom or celery for a different taste.
- Add chopped cooked bacon or sautéed mushrooms for extra depth.
- For a lighter option, substitute sour cream with plain Greek yogurt.
- Mix in fresh herbs like thyme or parsley to brighten the flavors.
Storage
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat individual portions in the microwave or warm the whole casserole in the oven at 350°F until heated through. For longer storage, freeze before baking; thaw overnight in the refrigerator and bake as directed.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use fresh vegetables instead of frozen?
Yes, fresh vegetables like peas, carrots, and corn can be used. Make sure to blanch or steam them slightly before adding to avoid excess moisture in the casserole.
Can I make this casserole ahead of time?
Absolutely. Prepare the casserole up to the baking step, cover, and refrigerate for up to 24 hours. Then bake as directed, adding a few extra minutes if baking from cold.
PrintChicken Bubble Biscuit Bake Casserole Recipe
This Chicken Bubble Biscuit Bake Casserole is a comforting and easy-to-make dish combining tender cooked chicken, mixed vegetables, creamy sauce, and fluffy biscuit dough baked to golden perfection with melted cheese on top. It’s perfect for a family dinner or potluck, delivering hearty flavors and a delightful texture that everyone will love.
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Total Time: 50 minutes
- Yield: 6 servings 1x
- Category: Casserole
- Method: Baking
- Cuisine: American
Ingredients
Chicken Mixture
- 2 cups cooked chicken (shredded or diced, rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
Biscuit Topping
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Preheat Oven: Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish to prevent sticking and ensure easy cleanup.
- Mix the Filling: In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir everything until the mixture is well blended and creamy.
- Add Biscuits: Fold the quartered biscuit dough pieces into the chicken mixture ensuring each biscuit piece is coated with the creamy filling.
- Assemble Casserole: Pour the entire mixture into the prepared baking dish, spreading it evenly. Then sprinkle the shredded cheddar cheese evenly over the top of the casserole.
- Bake: Cover the baking dish with aluminum foil and bake in the preheated oven for 20 minutes. After that, remove the foil and bake for an additional 10 to 15 minutes or until the biscuits are puffed, golden brown, and cooked through.
- Finish and Serve: Optionally brush the biscuit tops with melted butter for a richer flavor and shine. Let the casserole cool slightly before serving to allow it to set and make serving easier.
Notes
- You can substitute cream of chicken soup with cream of mushroom for a different flavor.
- If you prefer, use plain Greek yogurt instead of sour cream for a tangier taste and added protein.
- Frozen mixed vegetables can be customized based on your preference or what you have on hand.
- Using rotisserie chicken saves prep time and adds great flavor.
- For a crispier biscuit topping, you can broil the casserole for 1-2 minutes at the end, watching carefully to avoid burning.
- Allow the casserole to cool for at least 5 minutes to help it set for easier slicing and serving.
Keywords: Chicken casserole, biscuit bake, comforting dinner, easy casserole, chicken and biscuits, cheesy chicken bake, quick family meal

